MEDICAL RESOURCES

Peposertib (M3814) DNA-PK inhibitor

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• Peposertib (also known as M3814 and MSC2490484A) is an investigational small-molecule inhibitor of DNA-PK, a key enzyme in the double-strand break (DSB) repair pathway

• DNA-PK inhibition is thought to delay DNA repair of the DSB pathway in solid tumors and hematologic malignancies

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